@article{Narsaria_Singh_Mishra_Luthra_2015, title={Pro-oxidants in pathogenesis of severe malaria in children}, volume={27}, url={https://iapsmupuk.org/journal/index.php/IJCH/article/view/582}, abstractNote={<p><strong>Introduction</strong>: Malaria is a major cause of morbidity and mortality in developing countries. The role of oxidants in the pathogenesis of malaria in children are lacking. <strong>Objective</strong>: This study was done to assess the plasma oxidant level of children with severe malaria. <strong>Material and Methods</strong>: This prospective study was done in Mayo Institute of Medical Sciences, a tertiary care hospital. 40 patients of confirmed malaria in the age group of 0–16 years and other 40 age- and gender-matched healthy children (controls) were included in our study. Plasma malonyldialdehyde (MDA) was estimated by thiobarbituric acid test. Protein carbonyl level was analyzed by the methods of Reznick and Packer. <strong>Results:</strong> The average plasma level of oxidants was significantly higher in cases as compared to control group (p < 0.05). The plasma MDA level in the cases was significantly higher (p= 0.03) than in control group. The plasma level of protein carbonyl in cases was significantly higher (p = 0.038) as compared to control group. The plasma level of Copper (Cu) and Nitrite were also found significantly higher (p < 0.05) in cases. <strong>Conclusion</strong>: The plasma MDA, protein carbonyl, copper and nitrites were significantly raised in cases with severe malaria as compared to controls (p <0.05) reflecting the increased oxidative stress in cases as compared to controls.</p>}, number={3}, journal={Indian Journal of Community Health}, author={Narsaria, Nidhi and Singh, Ashutosh Kumar and Mishra, Pankaj Kumar and Luthra, Megha}, year={2015}, month={Sep.}, pages={346–350} }