TY - JOUR AU - Gayathri, G AU - Hemamalini, AJ PY - 2020/12/31 Y2 - 2024/03/28 TI - Plant based Indigenous Dietary Calcium supplementation on Bone turnover markers among Peri and Postmenopausal women: A Randomised Controlled Trial JF - Indian Journal of Community Health JA - Indian J Community Health VL - 32 IS - 4 SE - Original Article DO - 10.47203/IJCH.2020.v32i04.016 UR - https://iapsmupuk.org/journal/index.php/IJCH/article/view/1911 SP - 705-712 AB - <p><strong>Background: </strong>Indigenous plant based dietary supplement that is accessible and safer may help to combat the more proclaimed calcium deficiency among Indian population and improve bone strength. <strong>Aim &amp; Objective: </strong>To formulate an indigenous calcium rich food supplement and study its impact on markers of bone resorption and formation. <strong>Settings and Design: </strong>Sixty subjects (80% power, ? = 0.05) including 30 perimenopausal and postmenopausal women each were randomly assigned to control and experimental groups. <strong>Methods and Material</strong>: Experimental postmenopausal and perimenopausal women received 1200mg and 800mg per day of calcium respectively from a plant based supplement comprising Sesamum indicum, Eleusine coracana, Glycine max Vigna mungo and Sesbania grandiflora as a midmorning and evening snack. Measures like serum calcium, betacrosslaps (bone resorption marker), total P1NP (bone formation marker) were assessed at baseline, 3rd and 6th month. <strong>Results: </strong>Fifty-seven subjects were analysed with no adverse events were reported. Results showed that after supplementation betacrosslaps reduced from 0.32±0.130 ng/ml to 0.25±0.130 ng/ml and 1.11±0.290 ng/ml to 0.42±0.263 ng/ml in perimenopausal and postmenopausal subjects significant at (P=0.008) and (P=0.012) respectively. <strong>Conclusions: </strong>Adequate dietary calcium intake using locally available foods is recommended as a strategic option in reducing risk of osteoporosis.</p> ER -