Impact of vitamin D deficiency on cancer incidence and mortality among the elderly population: A systematic review
DOI:
https://doi.org/10.47203/IJCH.2019.v31i02.003Keywords:
Vitamin D, Cancer, Vitamin D Deficiency, Breast CancerAbstract
Abstract Vitamin D plays a vital role in calcium and phosphate balance and bone structure. In recent times vitamin D deficiency has become a well-known epidemic. The current study shows vitamin D deficiency causes various types of cancer along with heart disease. The current diet has removed most of the best sources of vitamin D. Healthy bones and teeth need vitamin D. Most of the low fat diets have removed vitamin D from the diet. Vitamin D has to be consumed with fatty meal. Food items such as dairy products are hardly fortified with vitamin D in India. Subclinical vitamin D deficiency is extremely prevalent in both urban and rural settings. In USA and Canada, in spite of having food fortification techniques still vitamin D deficiency prevails. In this paper various case studies related to vitamin D deficiency in relation to cancer have been reviewed. A proper diet to overcome this problem have been suggested along with some preventive measures
Downloads
References
Giovannucci E. Vitamin D and cancer incidence in the Harvard cohorts. Ann Epidemiol. 2009 Feb;19(2):84-8. doi: 10.1016/j.annepidem.2007.12.002. Epub 2008 Mar 4. Review. PubMed PMID: 18291673.[PubMed].
Gocek E, Studzinski GP. Vitamin D and differentiation in cancer. Crit Rev Clin Lab Sci. 2009;46(4):190-209. doi: 10.1080/10408360902982128. Review. PubMed PMID: 19650715; PubMed Central PMCID: PMC2820234. [PubMed].
Koralek DO, Bertone-Johnson ER, Leitzmann MF, Sturgeon SR, Lacey JV Jr, Schairer C, Schatzkin A. Relationship between calcium, lactose, vitamin D, and dairy products and ovarian cancer. Nutr Cancer. 2006;56(1):22-30. doi: 10.1207/s15327914nc5601_4. PubMed PMID: 17176214. [PubMed].
Bjelakovic, G., Gluud, L. L., Nikolova, D., Whitfield, K., Wetterslev, J., Simonetti, R. G., & Gluud, C. (2014). Vitamin D supplementation for prevention of mortality in adults. Cochrane database of systematic reviews, (1).
Forrest KY, Stuhldreher WL. Prevalence and correlates of vitamin D deficiency in US adults. Nutr Res. 2011 Jan;31(1):48-54. doi: 10.1016/j.nutres.2010.12.001. PubMed PMID: 21310306. [PubMed].
Krishnan, A. V., Trump, D. L., Johnson, C. S., & Feldman, D. (2012). The role of vitamin D in cancer prevention and treatment. Rheumatic Disease Clinics, 38(1), 161-178.
Krishnan AV, Feldman D. Mechanisms of the anti-cancer and anti-inflammatory actions of vitamin D. Annu Rev Pharmacol Toxicol. 2011;51:311-36. doi: 10.1146/annurev-pharmtox-010510-100611. Review. PubMed PMID: 20936945. [PubMed].
Peppone, L. J., Huston, A. J., Reid, M. E., Rosier, R. N., Zakharia, Y., Trump, D. L., ... & Morrow, G. R. (2011). The effect of various vitamin D supplementation regimens in breast cancer patients. Breast cancer research and treatment, 127(1), 171-177.
Samimi M, Touzé A, Laude H, Le Bidre E, Arnold F, Carpentier A, Gardair C, Carlotti A, Maubec E, Dupin N, Aubin F, Avril MF, Rozenberg F, Avenel-Audran M, Guyetant S, Lorette G, Machet L, Coursaget P. Vitamin D deficiency is associated with greater tumor size and poorer outcome in Merkel cell carcinoma patients. J Eur Acad Dermatol Venereol. 2014 Mar;28(3):298-308. doi: 10.1111/jdv.12101. Epub 2013 Feb 1. PubMed PMID: 23368852. [PubMed].
Autier, P., Boniol, M., Pizot, C., & Mullie, P. (2014). Vitamin D status and ill health: a systematic review. The lancet Diabetes & endocrinology, 2(1), 76-89.
Bolland, M. J., Grey, A., Gamble, G. D., & Reid, I. R. (2014). The effect of vitamin D supplementation on skeletal, vascular, or cancer outcomes: a trial sequential meta-analysis. The lancet Diabetes & endocrinology, 2(4), 307-320.
Chowdhury R, Kunutsor S, Vitezova A, Oliver-Williams C, Chowdhury S, Kiefte-de-Jong JC, Khan H, Baena CP, Prabhakaran D, Hoshen MB, Feldman BS, Pan A, Johnson L, Crowe F, Hu FB, Franco OH. Vitamin D and risk of cause specific death: systematic review and meta-analysis of observational cohort and randomised intervention studies. BMJ. 2014 Apr 1;348:g1903. doi: 10.1136/bmj.g1903. Review. PubMed PMID: 24690623; PubMed Central PMCID: PMC3972416. [PubMed]
Feldman D, Krishnan AV, Swami S, Giovannucci E, Feldman BJ. The role of vitamin D in reducing cancer risk and progression. Nat Rev Cancer. 2014 May;14(5):342-57. doi: 10.1038/nrc3691. Epub 2014 Apr 4. Review. PubMed PMID: 24705652. [PubMed]
Theodoratou E, Tzoulaki I, Zgaga L, Ioannidis JP. Vitamin D and multiple health outcomes: umbrella review of systematic reviews and meta-analyses of observational studies and randomised trials. BMJ. 2014 Apr 1;348:g2035. doi: 10.1136/bmj.g2035. Review. PubMed PMID: 24690624; PubMed Central PMCID: PMC3972415. [PubMed]
Miller JW, Harvey DJ, Beckett LA, Green R, Farias ST, Reed BR, Olichney JM, Mungas DM, DeCarli C. Vitamin D Status and Rates of Cognitive Decline in a Multiethnic Cohort of Older Adults. JAMA Neurol. 2015 Nov;72(11):1295-303. doi: 10.1001/jamaneurol.2015.2115. PubMed PMID: 26366714; PubMed Central PMCID: PMC5023277. [PubMed]
Oh MG, Han MA, Park J, Ryu SY, Choi SW. The Prevalence of Vitamin D Deficiency among Cancer Survivors in a Nationwide Survey of the Korean Population. PLoS One. 2015;10(6):e0129901. doi: 10.1371/journal.pone.0129901. eCollection 2015. PubMed PMID: 26047013; PubMed Central PMCID: PMC4457839. [PubMed].
Ordóñez-Mena, J. M., Schöttker, B., Fedirko, V., Jenab, M., Olsen, A., Halkjær, J., & Peeters, P. H. (2016). Pre-diagnostic vitamin D concentrations and cancer risks in older individuals: an analysis of cohorts participating in the CHANCES consortium. European journal of epidemiology, 31(3), 311-323.
Aguirre, M., Manzano, N., Salas, Y., Angel, M., Díaz-Couselo, F. A., & Zylberman, M. (2016). Vitamin D deficiency in patients admitted to the general ward with breast, lung, and colorectal cancer in Buenos Aires, Argentina. Archives of osteoporosis, 11(1), 4.
Qin B, Moorman PG, Alberg AJ, Barnholtz-Sloan JS, Bondy M, Cote ML, Funkhouser E, Peters ES, Schwartz AG, Terry P, Schildkraut JM, Bandera EV. Dairy, calcium, vitamin D and ovarian cancer risk in African-American women. Br J Cancer. 2016 Oct 25;115(9):1122-1130. doi: 10.1038/bjc.2016.289. Epub 2016 Sep 15. PubMed PMID: 27632371; PubMed Central PMCID: PMC5117784. [PubMed]
Park SM, Li T, Wu S, Li WQ, Qureshi AA, Cho E. Vitamin D Intake and Risk of Skin Cancer in US Women and Men. PLoS One. 2016;11(8):e0160308. doi: 10.1371/journal.pone.0160308. eCollection 2016. PubMed PMID: 27557122; PubMed Central PMCID: PMC4996491. [PubMed]
Lappe J, Watson P, Travers-Gustafson D, Recker R, Garland C, Gorham E, Baggerly K, McDonnell SL. Effect of Vitamin D and Calcium Supplementation on Cancer Incidence in Older Women: A Randomized Clinical Trial. JAMA. 2017 Mar 28;317(12):1234-1243. doi: 10.1001/jama.2017.2115. PubMed PMID: 28350929. [PubMed]
de Sousa Almeida-Filho B, De Luca Vespoli H, Pessoa EC, Machado M, Nahas-Neto J, Nahas EAP. Vitamin D deficiency is associated with poor breast cancer prognostic features in postmenopausal women. J Steroid Biochem Mol Biol. 2017 Nov;174:284-289. doi: 10.1016/j.jsbmb.2017.10.009. Epub 2017 Oct 12. PubMed PMID: 29031688. [PubMed]
Ismail, A., El-Awady, R., Mohamed, G., Hussein, M., & Ramadan, S. S. (2018). Prognostic Significance of Serum Vitamin D Levels in Egyptian Females with Breast Cancer. Asian Pacific journal of cancer prevention: APJCP, 19(2), 571
Downloads
Published
How to Cite
License
Copyright (c) 2019 Indian Journal of Community Health
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.