Proportion of Non-Alcoholic Fatty Liver Disease and Its Risk Factors among Sedentary Workers of a Tertiary Care Centre: Camp-Based Findings
DOI:
https://doi.org/10.47203/IJCH.2025.v37i05.011Keywords:
NAFLD, Sedentary Workers, Fibrosis, Steatosis, Screening, IndiaAbstract
Background: A growing public health problem is non-alcoholic fatty liver disease (NAFLD), especially in sedentary workers. The purpose of this study was to estimate the proportion of sedentary tertiary care hospital staff who had NAFLD and related risk factors. Methods: In North India, a tertiary care facility held a cross-sectional screening camp for sedentary employees. Fibrosis was evaluated using liver stiffness measurement (LSM), while steatosis was evaluated using the ultrasound attenuation parameter (UAP). Data on socio demographics, lifestyle, and comorbidities were collected by a self-designed questionnaire filled by the investigator. All participants were on fasting before testing. Results: Among 211 participants (83.4% male; mean age 34.5 ± 7.11 years), advanced fibrosis (F3–F4) was detected in 10.4% and severe steatosis (S3) in 26.5%. Steatosis grade was significantly associated with age and gender. On multivariable analysis, age independently predicted severe steatosis (30–39 years: AOR 2.76, p = 0.013; ?40 years: AOR 4.60, p = 0.009), while gender and other factors were not significant. UAP-based steatosis grades were associated with LSM-based fibrosis stages (p = 0.006). No missing data were observed. Conclusions: A substantial burden of NAFLD-related fibrosis and steatosis was detected among sedentary workers. Workplace-based screening and lifestyle interventions are recommended.
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References
Younossi ZM, Koenig AB, Abdelatif D, Fazel Y, Henry L, Wymer M. Global epidemiology of nonalcoholic fatty liver disease—meta-analytic assessment of prevalence, incidence, and outcomes. Hepatology. 2016;64(1):73–84.
Rinella ME. Nonalcoholic fatty liver disease: a systematic review. JAMA. 2015 Jun 9;313(22):2263–73.
Chalasani N, Younossi Z, Lavine JE, Diehl AM, Brunt EM, Cusi K, et al. The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association. Hepatology. 2012 Jun;55(6):2005–23.
Singh SP, Nayak S, Swain M, Rout N, Mallik RN, Agrawal O, et al. Prevalence of nonalcoholic fatty liver disease in coastal eastern India: a preliminary ultrasonographic survey. Trop Gastroenterol. 2004;25(2):76–9.
World Health Organization. Global action plan on physical activity 2018–2030: more active people for a healthier world [Internet]. Geneva: World Health Organization; 2018. Available from: https://iris.who.int/handle/10665/272722. Cited 2025 Oct 25.
Ryu S, Chang Y, Jung HS, Yun KE, Kwon MJ, Choi Y, et al. Relationship of sitting time and physical activity with non-alcoholic fatty liver disease. J Hepatol. 2015 Nov;63(5):1229–37.
Bhargava B, Rao PN, Kulkarni AV, Vishnubhotla R, Pramod N, Anitha CT, et al. Prevalence of metabolic dysfunction-associated fatty liver disease among information technology employees in India. Sci Rep. 2025;24;15(1):10124.
Song E, Kim JA, Roh E, Yu JH, Kim NH, Yoo HJ, et al. Long working hours and risk of nonalcoholic fatty liver disease: Korea National Health and Nutrition Examination Survey VII. Front Endocrinol (Lausanne). 2021;12:647459.
Wang J, Chiu WH, Chen RC, Chen FL, Tung TH. The clinical investigation of disparity of nonalcoholic fatty liver disease in a Chinese occupational population in Taipei, Taiwan: experience at a teaching hospital. Asia Pac J Public Health. 2015 Mar;27(2):NP1793–804.
European Association for the Study of the Liver (EASL); European Association for the Study of Diabetes (EASD); European Association for the Study of Obesity (EASO). EASL–EASD–EASO clinical practice guidelines for the management of non-alcoholic fatty liver disease. J Hepatol. 2016 Jun;64(6):1388–402.
Castera L, Friedrich-Rust M, Loomba R. Noninvasive assessment of liver disease in patients with nonalcoholic fatty liver disease. Gastroenterology. 2019;156(5):1264–1281.
European Association for Study of Liver; Asociacion Latinoamericana para el Estudio del Higado. EASL-ALEH clinical practice guidelines: non-invasive tests for evaluation of liver disease severity and prognosis. J Hepatol. 2015;63(1):237–64.
de Lédinghen V, Vergniol J, Capdepont M, Chermak F, Hiriart JB, Cassinotto C, et al. Controlled attenuation parameter (CAP) for the diagnosis of steatosis: a prospective study of 5323 examinations. J Hepatol. 2014 May;60(5):1026–31.
Singhai A, Yadav V, Joshi R, Malik R, T SB, Kamle S. Prevalence, metabolic profile, and associated risk factors of non-alcoholic fatty liver disease in an adult population of India. Cureus [Internet]. 2023 Jan 19 [cited 2025 Oct 25]. Available from: https://www.cureus.com/articles/133845-prevalence-metabolic-profile-and-associated-risk-factors-of-non-alcoholic-fatty-liver-disease-in-an-adult-population-of-india.
Amarapurkar DN, Hashimoto E, Lesmana LA, Sollano JD, Chen PJ, Goh KL, et al. How common is non-alcoholic fatty liver disease in the Asia-Pacific region and are there local differences? J Gastroenterol Hepatol. 2007 Jun;22(6):788–93.
Vishnu Prasad NR, Shabana J, Sudharshnan S, Hamide A, Subhathra A, Sahu SK. Prevalence of NAFLD among nursing staff in a medical institute in South India—a cross-sectional study. HPB. 2019;21(Suppl 1):S400.
Singh SP, Singh A, Misra D, Misra B, Pati GK, Panigrahi MK, et al. Risk factors associated with non-alcoholic fatty liver disease in Indians: a case–control study. J Clin Exp Hepatol [Internet]. 2015;5(4):295–302.
Pierantonelli I, Svegliati-Baroni G. Nonalcoholic fatty liver disease: basic pathogenetic mechanisms in the progression from NAFLD to NASH. Transplantation. 2019;103(1):e1–13.
Malaguarnera M, Di Rosa M, Nicoletti F, Malaguarnera L. Molecular mechanisms involved in NAFLD progression. J Mol Med (Berl). 2009 Jul;87(7):679–95.
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