Assessment of Knowledge, Attitude, and Practices towards Hydroxychloroquine Pre-exposure Prophylaxis for COVID-19 among Health Care Professionals

  • Arpita Singh
  • Hemant Kumar
  • Preeti Gupta
  • Ajay Kumar Verma
  • Atul Jain
  • Surya Kant
  • Anuj Kumar Pandey
  • S K Singh
Keywords: Hydroxychloroquine, Pre-exposure prophylaxis, Health care professionals, COVID-19

Abstract

Background: There is an urgent need for developing potential drug targets to protect the health care professionals (HCPs) who are at high risk of infection from corona virus disease-2019 (COVID-19) as they are directly and/ indirectly involved in treatment facility. We aimed to assess knowledge, attitude, and practices towards hydroxychloroquine (HCQ) pre-exposure prophylaxis (PEP) among HCPs directly and/ indirectly involved in COVID-19 treatment.

Materials and Methods

This cross-sectional study was multi-centric, and data was collected from HCPs (only doctors and nurses) involved directly or indirectly with COVID-19 patient treatment. The study questionnaire consisted of socio-demographic profile; assessment of HCQ knowledge, attitude, practices, and related adverse drug reactions (ADRs).

Results

Of the recruited 374 HCPs, 302 fulfilled the study criteria. Mean age of participants was 33.30 {±standard deviation 7.65}. 64.2% of the participants were male.16.9% of the individuals (n=51) had co-morbidities. All the HCPs had basic knowledge of COVID-19 and 87.42% were aware of the role of HCQ as PEP. Further, 269 participants (89.07%) were aware that HCQ can cause adverse drug reactions (ADRs).  56.6% participants agreed that HCQ had a protective role against COVID-19 and 54.3 % participants considered that PEP with HCQ had ‘more benefit’ than risk. 52.32% (n=158) HCPs had used HCQ as PEP and 52.53% (n=83) of these participants had completed the recommended drug course. Twenty participants (12.67%) had experienced ADR, and 12 had reported it to ADR monitoring centre.

Conclusion

Our data shows that HCPs are aware of COVID-19 and HCQ prophylaxis. Approximately 57% of the participants agreed that it has a protective role against COVID-19 and 50% of the participants had taken HCQ prophylaxis. Only 12.67% of the participants reported an ADR and in none of them, it was serious enough to discontinue the drug.

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Published
2020-12-31
How to Cite
1.
Singh A, Kumar H, Gupta P, Verma AK, Jain A, Kant S, Pandey AK, Singh SK. Assessment of Knowledge, Attitude, and Practices towards Hydroxychloroquine Pre-exposure Prophylaxis for COVID-19 among Health Care Professionals. Indian J Community Health [Internet]. 2020Dec.31 [cited 2021Jan.21];32(4). Available from: https://iapsmupuk.org/journal/index.php/IJCH/article/view/1866
Section
Original Article

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