Plant based Indigenous Dietary Calcium supplementation on Bone turnover markers among Peri and Postmenopausal women: A Randomised Controlled Trial
Keywords:Dietary Calcium, Bone Turnover, Betacrosslaps
Background: Indigenous plant based dietary supplement that is accessible and safer may help to combat the more proclaimed calcium deficiency among Indian population and improve bone strength. Aim & Objective: To formulate an indigenous calcium rich food supplement and study its impact on markers of bone resorption and formation. Settings and Design: Sixty subjects (80% power, ? = 0.05) including 30 perimenopausal and postmenopausal women each were randomly assigned to control and experimental groups. Methods and Material: Experimental postmenopausal and perimenopausal women received 1200mg and 800mg per day of calcium respectively from a plant based supplement comprising Sesamum indicum, Eleusine coracana, Glycine max Vigna mungo and Sesbania grandiflora as a midmorning and evening snack. Measures like serum calcium, betacrosslaps (bone resorption marker), total P1NP (bone formation marker) were assessed at baseline, 3rd and 6th month. Results: Fifty-seven subjects were analysed with no adverse events were reported. Results showed that after supplementation betacrosslaps reduced from 0.32±0.130 ng/ml to 0.25±0.130 ng/ml and 1.11±0.290 ng/ml to 0.42±0.263 ng/ml in perimenopausal and postmenopausal subjects significant at (P=0.008) and (P=0.012) respectively. Conclusions: Adequate dietary calcium intake using locally available foods is recommended as a strategic option in reducing risk of osteoporosis.
Lambert M, Hu L, Jeppesen P. A systematic review and meta-analysis of the effects of isoflavone formulations against estrogen-deficient bone resorption in peri- and postmenopausal women. The American Journal of Clinical Nutrition 2017;106(3): 801-811
Bonjour JP, Benoit V, Rousseau B, Souberbielle JC. Consumption of vitamin D-and calcium-fortified soft white cheese lowers the biochemical marker of bone resorption TRAP 5b in postmenopausal women at moderate risk of osteoporosis fracture. J Nutr. 2012;142(4):698-703. doi: 10.3945/jn.111.153692. Epub 2012 Feb 22. PMID: 22357739.[PubMed].
Bolland MJ, Grey A, Avenell A, Gamble GD, Reid IR. Calcium supplements with or without vitamin D and risk of cardiovascular events: reanalysis of the Women's Health Initiative limited access dataset and meta-analysis. BMJ. 2011 19;342:d2040. doi: 10.1136/bmj.d2040. PMID: 21505219; PMCID: PMC3079822.[PubMed].
Lee KJ, Kim KS, Kim HN, Seo JA, Song SW. Association between dietary calcium and phosphorus intakes, dietary calcium/phosphorus ratio and bone mass in the Korean population. Nutr J. 2014 13;13(1):114. doi: 10.1186/1475-2891-13-114. PMID: 25496564; PMCID: PMC4292818.[PubMed].
Aptel I, Cance-Rouzaud A, Grandjean H. Association between calcium ingested from drinking water and femoral bone density in elderly women: evidence from the EPIDOS cohort. J Bone Miner Res. 1999;14(5):829-33. doi: 10.1359/jbmr.19188.8.131.529. PMID: 10320532.[PubMed].
Malathy S, Gayathri G, Hemamalini AJ. Developing and validating food frequency questionnaire to assess dietary intake of calcium in adults. International Journal of Food and Nutritional Science 2013; 2: 113- 115.
Gayathri G and Hemamalini A J. Dietary Calcium Intake Among Adults. Indian Journal of Research 2017;6(1)
Sindhu latha A P., Gayathri G and Hemamalini A J. Dietary Calcium Intake Among Adults-A Quantitative Assessment. International Journal of Recent Scientific Researc 2017;8(6), 17765-17767.
Gayathri G and Hemamalini A J. Development of an indigenous calcium rich food supplement. International Journal of Home Science 2017; 3(2): 80-84
Brian L. Intermediate Nutrition. 1st ed. california: Human Nutrition (FNDH 400) Flexbook; https://med.libretexts.org/Bookshelves/Nutrition/Book%3A_Intermediate_Nutrition_(Lindshield), 2020
Gibson RS, Bailey KB, Gibbs M, Ferguson EL. A review of phytate, iron, zinc, and calcium concentrations in plant-based complementary foods used in low-income countries and implications for bioavailability. Food Nutr Bull. 2010;31(2 Suppl): S134-46. doi: 10.1177/15648265100312S206. PMID: 20715598.[PubMed].
Weaver CM, Proulx WR, Heaney R. Choices for achieving adequate dietary calcium with a vegetarian diet. Am J Clin Nutr. 1999;70(3 Suppl):543S-548S. doi: 10.1093/ajcn/70.3.543s. PMID: 10479229.[PubMed].
Yang J, Punshon T, Guerinot ML, Hirschi KD. Plant calcium content: ready to remodel. Nutrients. 2012 Aug;4(8):1120-36. doi: 10.3390/nu4081120. Epub 2012 21. PMID: 23016135; PMCID: PMC3448090.[PubMed].
Kruger MC, Ha PC, Todd JM, Kuhn-Sherlock B, Schollum LM, Ma J, Qin G, Lau E. High-calcium, vitamin D fortified milk is effective in improving bone turnover markers and vitamin D status in healthy postmenopausal Chinese women. Eur J Clin Nutr. 2012;66(7):856-61. doi: 10.1038/ejcn.2012.54. Epub 2012 May 30. PMID: 22644348.[PubMed]
How to Cite
Copyright (c) 2020 Indian Journal of Community Health
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.