Role of probiotics and vitamins in maintaining a healthy gut microbiome: recent advances

Authors

DOI:

https://doi.org/10.47203/IJCH.2021.v33i03.027

Keywords:

Probiotics, Microbiome, Psychobiotics, Gut-Brain Axis, Depression, Anxiety

Abstract

While the concept of probiotics is not new, science based approaches to developing targeted probiotic products are a renewed interest. Probiotics and the microbiome is now being considered as having a blueprint of good health, unique to every human.  Along with the well-known and established health benefits like reduced antibiotic associated diarrhoea and colic symptoms, eczema, necrotising enterocolitis, acute paediatric infections like diahorrea and upper respiratory tract infections; probiotics are now considered as beneficial for maintaining mental well-being as well. This new branch of disease management is now termed as Nutritional neuroscience and these beneficial gut bacteria are referred to as psychobiotics. It is important to identify the specific strains of probiotics and characterize them and conduct randomised controlled trials to establish these benefits. With emerging data related to role of vitamins in modulating the gut microbiome, combining pre and probiotics with micronutrients is likely to result in powerful functional foods boosting host immunity.

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References

Food and Agriculture Organisation. Available at: http://www.fao.org/3/a0512e/a0512e.pdf(Accessed on 25/09/2021)

International Scientific Association for probiotics and Prebiotics. Available at: https://isappscience.org/for-scientists/resources/probiotics(Accessed on 25/09/2021)

Quigley EM. Gut bacteria in health and disease. Gastroenterology & hepatology. 2013; 9(9): 560–69.

Palmer C, Bik EM, DiGiulio DB, Relman DA, Brown PO. Development of the human infant intestinal microbiota. PLoS Biol. 2007;5(7):e177.

Fouhy F, Ross RP, Fitzgerald GF, Stanton C, Cotter PD. Composition of the early intestinal microbiota: knowledge, knowledge gaps and the use of high-throughput sequencing to address these gaps. Gut Microbes. 2012;3(3):203–20.

Marco ML, Sanders ME, GänzleM, Arrieta MC, Cotter PD, Vuyst LC, et al. The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on fermented foods. Nat Rev Gastroenterol Hepatol. 2021; 18: 196–208. https://doi.org/10.1038/s41575-020-00390-5

ILSI, India Status Paper on Probiotics, 2019 http://ilsi-india.org/PDF/Status_Paper_On_Role_of_Probiotics_In_Promoting_Healthy_Microbiome_For_Health_And_Immunity/Status_Paper_On_Role_of_Probiotics_In_Promoting_Healthy_Microbiome_For_Health_And_Immunity.pdf(Accessed on 25/09/2021)

Shi X, Zhang J, Mo L, Shi J, Qin M, & Huang X. Efficacy and safety of probiotics in eradicating Helicobacter pylori: A network meta-analysis. Medicine. 2019; 98(15), e15180. https://doi.org/10.1097/MD.0000000000015180

Wang Y, Li X, Ge T, Xiao, Y, Liao Y, Cui Y et al. Probiotics for prevention and treatment of respiratory tract infections in children, Medicine,2016; 95(31): e4509 doi: 10.1097/MD.0000000000004509

Laodong L, KangKang H, Qixiang S, Huan X, Lejin L, Moyu M, Chaoqian L. Probiotics for Preventing Upper Respiratory Tract Infections in Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Evidence-Based Complementary and Alternative Medicine, 2020; vol. 2020, Article ID 8734140, 8 pages. https://doi.org/10.1155/2020/8734140

Tan-Lim C and Esteban-Ipac N. Probiotics as treatment for food allergies among pediatric patients: a meta-analysis. The World Allergy Organization journal. 2018; 11(1): 25. https://doi.org/10.1186/s40413-018-0204-5

King, Tancredi D, Lenoir-Wijnkoop I, Gould K, Vann H, Connors G et al. Does probiotic consumption reduce antibiotic utilization for common acute infections? A systematic review and meta-analysis. European journal of public health, 2019; 29(3): 494–499. https://doi.org/10.1093/eurpub/cky185

Mohajeri MH, La Fata G, Steinert RE, Weber P. Relationship between the gut microbiome and brain function. Nutr Rev, 2018;76(7):481-496. doi: 10.1093/nutrit/nuy009.

Kalberer MM, Buchanan KL, Klien ME, Barth BB, Montoya MM, Shen X, Bohorquez DV. A gut-brain neural circuit for nutrient sensory transduction Science, 2018; 361(6408): eaat5236 DOI: 10.1126/science.aat5236

Parker A, Fonseca S and Carding SR. Gut microbes and metabolites as modulators of blood-brain barrier integrity and brain health. Gut Microbes, 2020; 11(2): 135-157, DOI: 10.1080/19490976.2019.1638722

Yano JM, Yu K, Donaldson GP, Shastri GG, Ann P, Ma L et al. Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis. Cell, 2015; 161(2): 264–276. https://doi.org/10.1016/j.cell.2015.02.047

Carabotti M, Scirocco A ,Maselli M A, and Severi C. The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems. Annals of gastroenterology, 2015; 28(2), 203–209.

Gazerani P. Probiotics for Parkinson’s Disease. International Journal of Molecular Sciences. 2019; 20(17):4121. https://doi.org/10.3390/ijms20174121

Butler MI, Sandhu K, Cryan JF, Dinan TG. From isoniazid to psychobiotics: the gut microbiome as a new antidepressant target. Br J Hosp Med (Lond). 2019; 80(3):139-145. doi: 10.12968/hmed.2019.80.3.139.PMID: 30860919

Pulikkan J, Maji A, Dhakan DB, Saxena R, Mohan B, Anto MM et al. Gut Microbial Dysbiosis in Indian Children with Autism Spectrum Disorders. Microbial ecology, 2018; 76(4), 1102–1114. https://doi.org/10.1007/s00248-018-1176-2

Huang F and Wu X. Brain Neurotransmitter Modulation by Gut Microbiota in Anxiety and Depression. Front Cell Dev Biol, 11 March 2021 https://doi.org/10.3389/fcell.2021.649103

Chen Y, Xu J, and Chen Y. Regulation of Neurotransmitters by the Gut Microbiota and Effects on Cognition in Neurological Disorders. Nutrients, 2021; 13(6), 2099. https://doi.org/10.3390/nu13062099

O’Toole P, Marchesi J and Hill C. Next-generation probiotics: the spectrum from probiotics to live biotherapeutics. Nat Microbiol, 2017 ; 2, 17057 https://doi.org/10.1038/nmicrobiol.2017.57

Tóth AG, Csabai I, Maróti G, Jerzsele A, Dubecz A, Patai AV et al. A glimpse of antimicrobial resistance gene diversity in kefir and yoghurt. Sci Rep , 2021; 10, 22458. https://doi.org/10.1038/s41598-020-80444-5(Accessed on 25/09/2021)

Steinert RE, Lee YK, Sybesma W. Vitamins for the Gut Microbiome. Trends Mol Med. 2020;26(2):137-140. doi: 10.1016/j.molmed.2019.11.005. Epub 2019 Dec 17.

Pham VT, Calatayud M, Rotsaert C, Seifert N, Richard N, Van den Abbeele P, Marzorati M, Steinert RE. Antioxidant Vitamins and Prebiotic FOS and XOS Differentially Shift Microbiota Composition and Function and Improve Intestinal Epithelial Barrier In Vitro. Nutrients. 2021;13(4):1125. doi: 10.3390/nu13041125.

Pham VT, Fehlbaum S, Seifert N, Richard N, Bruins MJ, Sybesma W, Rehman A, Steinert RE. Effects of colon-targeted vitamins on the composition and metabolic activity of the human gut microbiome- a pilot study. Gut Microbes. 2021;13(1):1-20. doi: 10.1080/19490976.2021.1875774.

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Published

2021-09-30

How to Cite

1.
Aeri BT. Role of probiotics and vitamins in maintaining a healthy gut microbiome: recent advances. Indian J Community Health [Internet]. 2021 Sep. 30 [cited 2024 Jun. 23];33(3):543-6. Available from: https://iapsmupuk.org/journal/index.php/IJCH/article/view/2236

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Current Updates