Molecular markers of Chloroquine resistance in India and Southeast Asia: A narrative review

Authors

  • Rakshita Maskeri Department of Pharmacology, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, India
  • Animesh Jain Department of Community Medicine, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, India https://orcid.org/0000-0003-0250-3608
  • Sheetal Ullal Department of Pharmacology, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, India https://orcid.org/0000-0002-9186-8846

Keywords:

Malaria, antimalarial, Chloroquine, resistance, India, Southeast Asia

Abstract

Abstract: Malaria is a major global public health problem mainly in the tropics and subtropics. Malaria control and elimination strategies mainly rely on efficacious antimalarial drugs. At present the major hurdle faced by malaria control programs is the drug resistance to antimalarials. Molecular surveillance using genetic markers associated with resistance provides a valuable tool for detecting and tracking resistance as well as providing an in-depth understanding of the development and spread of resistance.  Despite numerous published literatures there are limited review articles on molecular markers of drug resistance. Hence a review was planned. An exhaustive literature search was performed on PUBMED using “malaria”, “resistance”, “molecular”, “antimalarial”, “Chloroquine”, “Pfcrt”, “Pfmdr”, “Pvcrt”, “Pvmdr”as key words. Data pertaining to India and Southeast Asia were included. This review showed the widespread presence of molecular markers of drug resistance in Plasmodium falciparum and development of resistance in Plasmodium vivax over the years in Southeast Asia and India. This can have implications on malaria elimination and treatment guidelines in this region.

 

Key words:  Malaria, antimalarial drugs, drug resistance, pfcrt, pfmdr, pvcrt, pvmdr, chloroquine, molecular makers, India, Southeast Asia

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Author Biography

Animesh Jain, Department of Community Medicine, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, India

Professor

Published

2021-10-28

How to Cite

1.
Maskeri R, Jain A, Ullal SD. Molecular markers of Chloroquine resistance in India and Southeast Asia: A narrative review. Indian J Community Health [Internet]. 2021 Oct. 28 [cited 2022 Jan. 17];33(4). Available from: https://iapsmupuk.org/journal/index.php/IJCH/article/view/2239

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Section

Review Article

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