Socio-Demographic and Clinical Profile of Drug Resistant Tuberculosis Patients in a Tertiary Care Centre of Kolkata

Basu et al.: Socio-Demographic and Clinical Profile of Drug Resistant Tuberculosis Patients

Authors

  • Rivu Basu R. G. Kar Medical College, Kolkata
  • Susmita Kundu R. G. Kar Medical College, Kolkata
  • Debabani Biswas R. G. Kar Medical College, Kolkata
  • Saswati Nath R. G. Kar Medical College, Kolkata
  • Arnab Sarkar
  • Archita Bhattacharya R. G. Kar Medical College, Kolkata

Keywords:

Tuberculosis, Multidrug-Resistant, Extensively Drug-Resistant Tuberculosis, Drug Resistance, Microbial, Chest X-ray, India

Abstract

Background: Drug resistant tuberculosis is a major public health threat that hinders progress in tuberculosis control worldwide. In 2019, India contributed highest cases of TB (27%) Worldwide. In 2019, 3.3% of new TB cases and 18% of previously treated cases had MDR/RRTB worldwide and India (27%) had the largest share of the global burden. This study was done to find out the sociodemographic and clinical profile of drug resistant TB patients. Methodology: It is an observational descriptive study with cross-sectional design, conducted at the drug resistant tuberculosis centre of R. G. Kar Medical College of Kolkata, West Bengal. Study Population consisted of the patients who were registered for the DR-TB regimen. Study duration was July 2016 –March 2017. Pre-tested, semi-structured schedule was designed to capture their sociodemographic profile, treatment history, clinical findings and available medical records. Data were compiled in MS Excel and analysed in IBM SPSS 23.0. Results: Out of 159 cases, 27% patients were between 21-30 years. Males were predominant (68.6%). Most patients (56.6%) were underweight (BMI<18.5kg/m2). HIV seropositivity was found in 4 (2.5%) cases. Among all cases, 81.1% had history of taking ATD and 34.4% was cured in previous episode of treatment. The commonest associated comorbidity was DM (15.7%). Rifampicin resistance (93.1%) was most common followed by Isoniazid (8.2%). Pallor was found among 94.3% patients. Most patients had bilateral (62.3%) and moderately extensive (57.2%) lesions in chest x-ray. Conclusion: DR-TB control should focus adequately on younger age group as numbers of resistance is increasing among them. Relapse in previously cured cases was found to be major contributor of DR-TB suspect cases. Though, Rifampicin resistance was so common but prevalence of resistance to 2nd line drugs is still low. Focus should be given on early detection of drug resistance in all TB cases and improvement of nutritional status of the TB patient.

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Author Biographies

Rivu Basu, R. G. Kar Medical College, Kolkata

Assistant Professor, Department of Community Medicine

Susmita Kundu, R. G. Kar Medical College, Kolkata

Professor and Head of the Department, Department of Respiratory Medicine

Debabani Biswas, R. G. Kar Medical College, Kolkata

Associate professor, Department of Respiratory Medicine

Saswati Nath, R. G. Kar Medical College, Kolkata

Associate professor, Department of Psychiatry

Archita Bhattacharya, R. G. Kar Medical College, Kolkata

Junior Resident, Department of Community Medicine

Published

2021-12-31

How to Cite

1.
Rivu Basu, Susmita Kundu, Debabani Biswas, Saswati Nath, Sarkar A, Archita Bhattacharya. Socio-Demographic and Clinical Profile of Drug Resistant Tuberculosis Patients in a Tertiary Care Centre of Kolkata: Basu et al.: Socio-Demographic and Clinical Profile of Drug Resistant Tuberculosis Patients. Indian J Community Health [Internet]. 2021 Dec. 31 [cited 2022 Jan. 17];33(4). Available from: https://iapsmupuk.org/journal/index.php/IJCH/article/view/2240

Issue

Section

Original Article (IAPSM Member PG Thesis Only)