Burden of hypothyroidism amongst type 2 diabetics and hypertensives in Lucknow: A cross sectional study


  • Saurabh Kashyap Integral Institute of Medical Sciences and Research, Integral University, Lucknow https://orcid.org/0000-0002-7645-9374
  • Mohammad Suhail Khan Integral Institute of Medical Sciences and Research, Integral University, Lucknow https://orcid.org/0000-0001-5382-8539
  • Anas Ahmad Khan Integral Institute of Medical Sciences and Research, Integral University, Lucknow https://orcid.org/0000-0002-6156-8738
  • M Z Idris Integral Institute of Medical Sciences and Research, Integral University, Lucknow
  • Ausaf Ahmad Integral Institute of Medical Sciences and Research, Integral University, Lucknow
  • Sheetal Verma King George`s Medical University, Lucknow




Type II Diabetes Mellitus, Hypertension, Hypothyroidism, Prevalence


Background: The prevalence of hypothyroidism is reported in 4%–5% of population in the developed world, while in Indian population it is reported in around one in ten adults. Aims & Objectives: This study was conducted to determine the prevalence of hypothyroidism in Indian patients with T2DM and hypertension. Material and methods: In this cross-sectional observational study, amongst adults who were aged 18 years and above and diagnosed T2DM, HTN, and T2DM + HTN who resided in the field practice areas of the Urban Health Training Centre of the Department of Community Medicine, Integral institute of medical sciences and research, Lucknow, India. The results were summarized by descriptive statistics. Results: Out of 300 persons questioned, 159 (53.0%) were females and 141 (47.0%) were males. It was found that the mean age of the overall population was 53.1±11.3 years, mean and standard deviation of thyroid function and glycemic indicators test, observed that the levels of fT3, fT4, TSH, and glycemic indicators like FPG, PPG and HbA1c were identical. Conclusion: Subclinical hypothyroid subjects should be regularly screened for HTN. Elderly patients had higher proportion of thyroid dysfunction.


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Author Biography

Mohammad Suhail Khan, Integral Institute of Medical Sciences and Research, Integral University, Lucknow

Assistant Professor, Department of Community Medicine


Saito I, Ito K, Saruta T. Hypothyroidism as a cause of hypertension. Hypertension. 1983;5(1):112-5. doi: 10.1161/01.hyp.5.1.112. PMID:6848458.[PubMed].

Chaker L, Bianco AC, Jonklaas J, Peeters RP. Hypothyroidism. Lancet. 2017 23;390(10101):1550-1562. doi: 10.1016/S0140-6736(17)30703-1. Epub 2017 Mar 20.PMID: 28336049; PMCID: PMC6619426.[PubMed].

Unnikrishnan AG, Kalra S, Sahay RK, Bantwal G, John M, Tewari N. Prevalence of hypothyroidism in adults: An epidemiological study in eight cities of India. Indian J Endocrinol Metab. 2013;17(4):647-52. doi: 10.4103/2230-8210.113755.PMID: 23961480; PMCID: PMC3743364.[PubMed]

Ravishankar, SN, Champakamalini, Venkatesh, Mohsin A. prospective study of thyroid - dysfunction in patients with Type 2 diabetes in general population. Archives of Medicine, 2013; 5(1): 1-9.

Cappola AR, Ladenson PW. Hypothyroidism and atherosclerosis. J Clin Endocrinol Metab. 2003;88(6):2438-44. doi: 10.1210/jc.2003-030398. PMID: 12788839.[PubMed]

Helfand M; U.S. Preventive Services Task Force. Screening for subclinical thyroid dysfunction in nonpregnant adults: a summary of the evidence for theU.S. Preventive Services Task Force. Ann Intern Med. 2004 20;140(2):128-41. doi: 10.7326/0003-4819-140-2-200401200-00015. PMID: 14734337.[PubMed].

Monzani F, Dardano A, Caraccio N. Does treating subclinical hypothyroidism improve markers of cardiovascular risk? Treat Endocrinol. 2006;5(2):65-81. doi: 10.2165/00024677-200605020-00001. PMID: 16542047.[PubMed].

Talwalkar P, Deshmukh V, Bhole M. Prevalence of hypothyroidism in patients with type 2 diabetes mellitus and hypertension in India: a cross-sectional observational study. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Dovepress. 2019;12 :369–376

Alberti KG, Zimmet PZ. Definition, diagnosis and classification of diabetesmellitus and its complications. Part 1: diagnosis and classification of diabetesmellitus provisional report of a WHO consultation. Diabet Med. 1998;15(7):539-53. doi: 10.1002/(SICI)1096-9136(19980 )15:7<539::AID- DIA668>3.0.CO;2-S. PMID: 9686693.[PubMed].

Misra A, Chowbey P, Makkar BM, Vikram NK, Wasir JS, Chadha D, Joshi SR, Sadikot S, Gupta R, Gulati S, Munjal YP; Concensus Group. Consensus statementfor diagnosis of obesity, abdominal obesity and the metabolic syndrome for AsianIndians and recommendations for physical activity, medical and surgical management. J Assoc Phsicians India. 2009;57:163-70. PMID: 19582986.[PubMed].

Dayan CM. Interpretation of thyroid function tests. Lancet. 2001 24;357(9256):619-24. doi: 10.1016/S0140-6736(00)04060-5. PMID: 11558500.[PubMed].

Demitrost L, Ranabir S. Thyroid dysfunction in type 2 diabetes mellitus: A retrospective study. Indian J Endocrinol Metab. 2012 Dec;16(Suppl 2):S334-5.doi: 10.4103/2230-8210.104080. PMID: 23565418; PMCID: PMC3603066.[PubMed].

Han C, He X, Xia X, Li Y, Shi X, Shan Z, Teng W. Subclinical Hypothyroidism and Type 2 Diabetes: A Systematic Review and Meta-Analysis. PLoS One. 2015 13;10(8):e0135233. doi: 10.1371/journal.pone.0135233. PMID: 26270348; PMCID: PMC4535849.[PubMed].

Devi MA, Singh NS, Singh LS. Thyroid hormone dysfunction in type 2 diabetic patients in urban areas of Manipur. Int J Pharm Sci Int. 2013;2:7–9.

Vikram VB, Kanitkar SA, Tamakuwala KK, et al. Thyroid dysfunction in patients with type 2 diabetes mellitus at tertiary care centre. Nat J Med Res. 2013;3:377–380.

Uppal V, Vij C, Bedi GK, Vij A, Banerjee BD. Thyroid disorders in patients of type 2 diabetes mellitus. Indian J Clin Biochem. 2013;28(4):336-41. doi:10.1007/s12291-012-0293-9. Epub 2013 Jan 3. PMID: 24426234; PMCID: PMC3783922.[PubMed]

Kadiyala R, Peter R, Okosieme OE. Thyroid dysfunction in patients with diabetes: clinical implications and screening strategies. Int J Clin Pract. 2010;64(8):1130-9. doi: 10.1111/j.1742-1241.2010.02376.x. PMID: 20642711.[PubMed]

Curnock AL, Dweik RA, Higgins BH, Saadi HF, Arroliga AC. High prevalence of hypothyroidism in patients with primary pulmonary hypertension. Am J Med Sci. 1999;318(5):289-92. doi: 10.1097/00000441-199911000-00001. PMID: 10555089.[PubMed].

Turchi F, Ronconi V, di Tizio V, Boscaro M, Giacchetti G. Blood pressure, thyroid-stimulating hormone, and thyroid disease prevalence in primary aldosteronism and essential hypertension. Am J Hypertens. 2011;24(12):1274-9. doi: 10.1038/ajh.2011.144. Epub 2011 Aug 18. PMID: 21850059.[PubMed]

Subekti I, Pramono LA, Dewiasty E, Harbuwono DS. Thyroid Dysfunction in Type 2 Diabetes Mellitus Patients. Acta Med Indones. 2017;49(4):314-323. PMID:29348381.[PubMed]




How to Cite

Kashyap S, Khan MS, Khan AA, Idris MZ, Ahmad A, Verma S. Burden of hypothyroidism amongst type 2 diabetics and hypertensives in Lucknow: A cross sectional study. Indian J Community Health [Internet]. 2020 Dec. 31 [cited 2024 Jun. 24];32(4):643-6. Available from: https://iapsmupuk.org/journal/index.php/IJCH/article/view/1623



Original Article