To study the prevalence of latent tuberculosis infection among medical students





Latent Tuberculosis Infection, Tuberculin Skin Testing, Purified Protein Derivative, Medical Students, Dental Students

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Original Article



Background: Risk of developing latent tuberculosis infection increases in medical students with their higher exposure to TB care facilities. Objective: To study the prevalence of latent TB infection among students attending professional degrees MBBS, BDS, MD, MS, MDS at King George’s Medical University, India. Methods: This study was carried out with Tuberculin skin testing among students and active TB cases were excluded. A standard dose of 0.1?mL of purified protein derivative was slowly injected intra dermally into non-dominant forearm. After 48-72 hours, the reaction was estimated by measuring the transverse diameter of the induration. Results: Total 561 students had given consent to get enrolled. Prevalence of latent tuberculosis infection was significant with period of clinical exposure (p-value < 0.05), average size of induration (p-value < 0.001), and history of prior Tuberculin Skin Test (p-value < 0.001). However it was not significant with the age (p-value > 0.05), gender (p-value > 0.05), and history of contact with active cases of TB (p-value > 0.05). Conclusion: The prevalence of latent tuberculosis infection is higher in post graduate students followed by interns and final year students due to more exposure to patients in wards and clinics at King George’s Medical University, India.

How to Cite

Dinkar PK, Kumar S, Kumar S, Verma SK, Kumar S, Kamal A, Chaudhary E. To study the prevalence of latent tuberculosis infection among medical students. Indian J Community Health [Internet]. 2022 Jun. 30 [cited 2022 Aug. 16];34(2):284-8. Available from:


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Programme GT. Latent TB Infection?: Updated and consolidated guidelines for programmatic management [Internet]. World Health Organization; 2018. Available from:

Global tuberculosis report s [Internet]. Available from:

Sharma N, Basu S, Chopra KK. Achieving TB elimination in India: The role of latent TB management. Indian J Tuberculosis. 2019;66(1):30–3.

Mahmood T. 40% of India’s population play host to the TB bacillus as a latent TB [Internet]. Oneindia. 2016. Available from: cent-of-india-s-population-play-host-the-tb-bacillus-as-latent-tuberculosis-2049544.html

Kinikar A, Chandanwale A, Kadam D, Joshi S, Basavaraj A, Pardeshi G, et al. High risk for latent tuberculosis infection among medical residents and nursing students in India. PLoS One [Internet]. 2019;14(7):e0219131. Available from:

Malaviya AN, Aggarwal VK, Rawat R, Baghel S, Thakran R, Zaheer Q, et al. Screening for latent tuberculosis infection among patients with rheumatoid arthritis in the era of biologics and targeted synthetic disease?modifying anti?rheumatic drugs in India, a high?burden TB country: The importance of Mantoux and Quantiferon? TB Gold tests. Int J Rheum Dis [Internet]. 2018;21(8):1563–71. Available from:

World Health Organisation: Tuberculosis Fact sheet 2018. [cited 2022 Jun 7]. Available from:

Diagnostic Standards and Classification of Tuberculosis in Adults and Children. [adopted: ATS Board of Directors, July 1999.] [endorsed by the Council of the Infectious Disease Society of America, September 1999]. Am J Respir Crit Care Med [Internet]. 2000;161(4 Pt 1):1376–95.

Toujani S, Cherif J, Mjid M, Hedhli A, Ouahchy Y, Beji M. Evaluation of Tuberculin Skin Test Positivity and Early Tuberculin Conversion among Medical Intern Trainees in Tunisia. Tanaffos. 2017;16(2):149-156.

Revised national tuberculosis control programme NATIONAL STRATEGIC PLAN FOR TUBERCULOSIS ELIMINATION 2017-2025 [Internet]. Available from: WriteReadData/NSP%20Draft%2020.02.2017%201.pdf

Serrano-Escobedo CJ, Enciso-Moreno JA, Monárrez-Espino J. Performance of tuberculin skin test compared to QFT-IT to detect latent TB among high-risk contacts in Mexico. Arch Med Res. 2013;44(3):242–8.

WHO Library Cataloguing-in-Publication Data: New laboratory diagnostic tools for tuberculosis control. [cited 2022 Jun 7]. Available from: 44036/9789241597487_eng.pdf

Sekandi JN, Kakaire R, Mutanga JN, Whalen CC, Zalwango S, Nkwata AK, et al. Low prevalence of tuberculin skin test boosting among community residents in Uganda. Am J Trop Med Hyg [Internet]. 2018;98(2):379–81.

George SA, Ko CA, Kirchner HL, Starke JR, Dragga TA, Mandalakas AM. The role of chest radiographs and tuberculin skin tests in tuberculosis screening of internationally adopted children. Pediatr Infect Dis J. 2011;30(5):387–91.

Jasmer RM, Nahid P, Hopewell PC. Clinical practice. Latent tuberculosis infection. N Engl J Med [Internet]. 2002;347(23):1860–6. Available from: .

National Immunization Schedule (NIS) for Infants, Children and Pregnant Women [cited 2022 Jun 7]. Available from:

Basavaraj A, Chandanwale A, Patil A, Kadam D, Joshi S, Gupte N, et al. Tuberculosis risk among medical trainees, Pune, India. Emerg Infect Dis [Internet]. 2016;22(3):541–3.

Tudor C, Van Der Walt ML, Dorman MB, Pan SE, Yenokyan WK. Clinical infectious diseases: an official publication of the Infectious Diseases Society of America. Vol. 62. KwaZulu-Natal, South Africa; 2016.

Mathew A, David T, Thomas K, Kuruvilla PJ, Balaji V, Jesudason MV, et al. Risk factors for tuberculosis among health care workers in South India: a nested case-control study. J Clin Epidemiol [Internet]. 2013;66(1):67–74.

Verso MG, Serra N, Ciccarello A, Romanin B, Di Carlo P. Latent tuberculosis infection among healthcare students and postgraduates in a Mediterranean Italian area: What correlation with work exposure? Int J Environ Res Public Health [Internet]. 2019;17(1):137.

Durando P, Alicino C, Orsi A, Barberis I, Paganino C, Dini G, et al. Latent tuberculosis infection among a large cohort of medical students at a Teaching Hospital in Italy. Biomed Res Int [Internet]. 2015;2015:1–6.

Lamberti M, Muoio MR, Westermann C, Nienhaus A, Arnese A, Ribeiro Sobrinho AP, et al. Prevalence and associated risk factors of latent tuberculosis infection among undergraduate and postgraduate dental students: A retrospective study. Arch Environ Occup Health [Internet]. 2017;72(2):99–105.

Praveen V. Prevalence of LTBI among household contacts of sputum positive TB patients receiving DOTS chemotherapy. Indian J Tuberc [Internet]. 2020;67(4):459–65.

Christopher DJ, Shankar D, Datey A, Zwerling A, Pai M. Safety of the two-step tuberculin skin test in Indian health care workers. Int J Mycobacteriol [Internet]. 2014;3(4):247–51.

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